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Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice
In spite of the great promises that the development of nanotechnologies can offer, concerns regarding potential adverse health effects of occupational exposure to nanoparticle (NP) is raised. We recently identified metal oxide NP in lung tissue sections of welders, located inside macrophages infiltrated in fibrous regions. This suggests a role of these NP in the lung alterations observed in welders. We therefore designed a study aimed to investigate the pulmonary effects, in mice, of repeated exposure to NP administered at occupationally relevant doses. We therefore chose four metal oxide NPs representative...
First order risk assessment for nanoparticle inhalation exposure during injection molding of polypropylene composites and production of tungsten-carbide-cobalt fine powder based upon pulmonary inflammation and surface area dose
Inhalation exposure to low toxicity and biodurable particles has shown to induce polymorphonuclear neutrophilia (PMN) in the lungs, which is a strong indicator for lung inflammation. Recently, Schmid and Stoeger (2016) reviewed mice and rat intratracheal instillation studies and assessed the relation between particles dry powder BET surface area dose and PMN influx for granular biodurable particles (GBPs) and transition metal oxides. In this study, we measured workers alveolar lung deposited surface area (LDSA) concentrations (μm2 cm− 3) during injection molding of polypropylene (PP) car...
Refinement of the Nanoparticle Emission Assessment Technique into the Nanomaterial Exposure Assessment Technique (NEAT 2.0)
Engineered nanomaterial emission and exposure characterization studies have been completed at more than 60 different facilities by the National Institute for Occupational Safety and Health (NIOSH). These experiences have provided NIOSH the opportunity to refine an earlier published technique, the Nanoparticle Emission Assessment Technique (NEAT 1.0), into a more comprehensive technique for assessing worker and workplace exposures to engineered nanomaterials. This change is reflected in the new name Nanomaterial Exposure Assessment Technique (NEAT 2.0) which distinguishes it from NEAT 1.0. NEAT...
Taking stock of the occupational safety and health challenges of nanotechnology: 2000–2015
Engineered nanomaterials significantly entered commerce at the beginning of the 21st century. Concerns about serious potential health effects of nanomaterials were widespread. Now, approximately 15 years later, it is worthwhile to take stock of research and efforts to protect nanomaterial workers from potential risks of adverse health effects. This article provides and examines timelines for major functional areas (toxicology, metrology, exposure assessment, engineering controls and personal protective equipment, risk assessment, risk management, medical surveillance, and epidemiology) to identify...
Occupational dermal exposure to nanoparticles and nano-enabled products
Part 2, exploration of exposure processes and methods of assessment In the first of a series of two papers (Larese Filon et al., 2016), we focused our attention on identifying conditions or situations, i.e. a combination of nanoparticle physico-chemical properties, skin barrier integrity, and occupations with high prevalence of skin disease, which deserve further investigation. This second paper focuses on the broad question of dermal exposure assessment to nanoparticles and attempts to give an overview of the mechanisms of occupational dermal exposure to nanoparticles and nano-enabled products...
Occupational dermal exposure to nanoparticles and nano-enabled products
Part I - Factors affecting skin absorption The paper reviews and critically assesses the evidence on the relevance of various skin uptake pathways for engineered nanoparticles, nano-objects, their agglomerates and aggregates (NOAA). It focuses especially in occupational settings, in the context of nanotoxicology, risk assessment, occupational medicine, medical/epidemiological surveillance efforts, and the development of relevant exposure assessment strategies. Skin uptake of nanoparticles is presented in the context of local and systemic health effects, especially contact dermatitis, skin barrier...
Control banding tools for occupational exposure assessment of nanomaterials
Ready for use in a regulatory context? The development, production and application of engineered nanomaterials are becoming more and more widespread. Because researchers, developers and industrial workers are the first in line to be exposed to potentially hazardous nanomaterials, appropriate occupational exposure assessment is a key area of concern. Therefore, a number of Control Banding (CB)-based tools have been developed in order to assess and manage the potential risks associated with occupational exposure to nanomaterials.In this paper we provide a comparative analysis of different nanomaterial...
Dioxyde de titane nanométrique
De la nécessité d'une valeur limite d'exposition professionnelle Dès 2005, l'INRS a souligné la nécessité d'engager une réflexion relative aux valeurs limites d'exposition professionnelle en lien avec les nanomatériaux en raison de leurs propriétés toxicologiques particulières. Cet article propose, à partir de l'analyse de travaux initiés depuis en Europe, au Japon et aux États-Unis, une valeur limite d'exposition professionnelle pour le dioxyde de titane nanométrique...
Building a Safety Program to Protect the Nanotechnology Workforce
A Guide for Small to Medium-Sized Enterprises The National Institute for Occupational Safety and Health (NIOSH) is pleased to present Building a Safety Program to Protect the Nanotechnology Workforce: A Guide for Small to Medium-Sized Enterprises . Responsible development of nanotechnologies includes considering and managing the potential, unintended consequences to human health and the environment that might accompany development and use of the technology. This guide will demonstrate that the key to ensuring the safety of your business, particularly when resources are limited, is to prevent occupational...
Demonstration of a Modelling-based Multi-criteria Decision Analysis Procedure for Prioritization of Occupational Risks from Manufactured Nanomaterials
Several tools to facilitate the Risk Assessment and Management of manufactured nanomaterials (MN) have been developed. Most of them require input data on physicochemical properties, toxicity and scenario-specific exposure information. However, such data are yet not readily available, and tools that can handle data gaps in a structured way to ensure transparent risk analysis for industrial and regulatory decision making are needed. This paper proposes such a quantitative risk prioritisation tool, based on a Multi-criteria Decision Analysis algorithm, which combines advanced exposure and dose-response...
Nanomatériaux dans le secteur des soins de santé
Les risques professionnels et leur prévention Le domaine de la nanotechnologie connaît une évolution rapide et l'utilisation de nanomatériaux est de plus en plus fréquente. Comme dans un grand nombre de secteurs, la nanotechnologie exerce une influence croissante sur le secteur des soins de santé, ce qui accentue le risque d'exposition des travailleurs aux nanomatériaux dans leur milieu professionnel. La nanotechnologie et les nanomatériaux dans les applications médicales peuvent offrir quantité d'avantages. Par exemple...
Ecotoxicologie des nanomatériaux
Nouvelles approches analytiques Quatre ans après la publication de la note ayant pour titre « Écotoxicologie des nanoparticules : avancées méthodologiques dans l'évaluation des risques» (1), cette note a pour objectif de refaire le bilan sur les progrès réalisés dans le domaine. En effet, la période de veille écoulée a été marquée par la publication de nombreuses revues de la littérature contenant notamment le mot-clef « analytical » : concept analytique, approche...
Reproductive and developmental toxicity of carbon-based nanomaterials
A literature review We summarized the findings of reproductive and developmental toxicity studies on carbon-based nanomaterials (CNMs). Placental transfer of fullerenes in rats and single-walled (SW) and multi-walled (MW) CNTs in mice was shown after intravenous injection. SWCNTs appeared to be embryolethal and teratogenic in mice when given by intravenous injection and induced death and growth retardation in chicken embryos. In mice-administered MWCNTs, fetal malformations after intravenous and intraperitoneal injections and intratracheal instillation, fetal loss after intravenous injection, behavioral...
Procédures et évaluation du potentiel pro-inflammatoire des nanoparticules
Plusieurs pays industrialisés, incluant le Canada, ont opté pour le développement des nanotechnologies étant donné le grand potentiel économique que cela représente. Au Québec, de nombreuses entreprises de production de nanoparticules (NP) sont déjà implantées et il y a fort à parier que d'autres suivront ce mouvement d'ici peu. Ce faisant, le nombre de travailleurs œuvrant dans les domaines des nanotechnologies en général ou dans la fabrication et synthèse des NP augmentera grandement...
Safe handling of nanomaterials and other advanced materials in workplaces
A rising number of companies, especially small and medium enterprises (SME), are active in the field of nanotechnology. For safe development of this industry, forethought of occupational safety and health considerations is important. This guideline on good working practice with nanomaterials addresses research institutions as well as SME industries. Four decision criteria are presented that support the reader in deriving the appropriate occupational safety measures in a comprehensible way. These occupational safety measures are tailored to the defined groups of nanomaterials and follow the precautionary...
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