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NIOSH Releases New Nanotechnology Workplace Design Recommendations
Realizing the promise of any scientific advancement requires understanding of its potential human health effects, and its safe and responsible development, even at the level of engineered nanomaterials, which can be nearly atomic-sized. The National Institute for Occupational Safety and Health (NIOSH) launched four new products this week intended to provide options to companies for controlling possible exposure of their workers to nanomaterials on the job. Engineered nanomaterials are intentionally produced to have at least one primary dimension less than 100 nanometers (nm). These very small particles...
Protecting Workers during the Handling of Nanomaterials
Engineered nanomaterials (ENMs) are materials that are intentionally produced to have at least one primary dimension less than 100 nanometers (nm). These materials have new or unique properties different from those of larger forms of the same material, making them desirable for specific product applications. The health effects associated with nanomaterials are not yet clearly understood, so it is important for producers and users of ENMs to reduce employee exposure and manage risks appropriately. In 2013, the National Institute for Occupational Safety and Health (NIOSH) published a compendium of...
Control of exposure to hexavalent chromium concentration in shielded metal arc welding fumes by nano-coating of electrodes
Background: Cr(VI) is a suspected human carcinogen formed as a by-product of stainless steel welding. Nano-alumina and nano-titania coating of electrodes reduced the welding fume levels. Objective: To investigate the effect of nano-coating of welding electrodes on Cr(VI) formation rate (Cr(VI) FR) from a shielded metal arc welding process. Methods: The core welding wires were coated with nano-alumina and nano-titania using the sol-gel dip coating technique. Bead-on plate welds were deposited on SS 316 LN plates kept inside a fume test chamber. Cr(VI) analysis was done using an atomic absorption...
Nanotechnology in construction and demolition
What we know, what we don’t Nanotechnology is an exciting, innovative area promising great benefits to many areas of life, industry and commerce, including construction and the built environment. However there remains concerns about the health impacts from nanotechnologies. We don’t know which materials contain nanoparticles; we don’t know which nanoparticles are present; we don’t know how easily they could become bio-available; and we don’t know what to do if they do become bio-available. This research, aimed to provide some clarity regarding the current use of nanomaterials...
WHO Guidelines to Protect Workers from Nanomaterials
The term nanomaterials refers to materials that have at least one dimension (height, width or length) that is smaller than 100 nanometres (10−7 metre), which is about the size of a virus particle. This particular size dimension represents a major characteristic of manufactured nanomaterials (MNMs). The unique properties of MNMs may result in highly desirable behaviour leading to such varying applications as better paints, better drugs and faster electronics. However, for the same reason, MNMs may also present health hazards that differ from those of the substance in bulk form, and may require...
Activation des éosinophiles humains par des nanoparticules
L'économie du Canada, comme celle de bien d'autres pays industrialisés, bénéficie du développement des nanotechnologies dont le fort potentiel peut être exploité dans plusieurs secteurs industriels. Un nombre croissant d'entreprises québécoises de production de nanoparticules (NP) est d'ailleurs déjà implanté et tout porte à croire que d'autres emboîteront le pas dans les années à venir. Ce faisant, non seulement le nombre de travailleurs œuvrant dans la fabrication...
Workplace exposure and release of ultrafine particles during atmospheric plasma spraying in the ceramic industry
Atmospheric plasma spraying (APS) is a frequently used technique to produce enhanced-property coatings for different materials in the ceramic industry. This work aimed to characterise and quantify the impact of APS on workplace exposure to airborne particles, with a focus on ultrafine particles (UFPs, < 100 nm) and nanoparticles (< 50 nm). Particle number, mass concentrations, alveolar lung deposited surface area concentration, and size distributions, in the range 10 nm–20 μm were simultaneously monitored at the emission source, in the potential worker breathing zone, and in outdoor...
Challenges on the toxicological predictions of engineered nanoparticles
The perceived enormous potential of nanotechnology in contributing to sustainable innovation has led to the growth of investments into new industrial applications and consumer products. However, the lack of tools that are needed to generate early knowledge about the potential adverse effects, combined with the uncertainties regarding the health and safety risks of engineered nanoparticles (ENPs), are a potential threat to the acceptability by society of the nanotechnology innovations, due to the rising societal concerns that are based on generic worries. In order to tackle these issues, it has...
Opportunité et risques des nanomatériaux
Le Programme national de recherche PNR 64 «Opportunités et risques des nanomatériaux» a démarré début 2010. 23 groupes de recherche de toute la Suisse ont examiné les opportunités et les risques présentés par les nanomatériaux synthétiques aux différents stades de leur cycle de vie. Parmi les groupes de recherche, celui mené par Mickael Riediker, ancien chef de groupe à l'IST, est le seul à s'être chargé d'investiguer l'impact des nanomatériaux...
Exposures to nanoparticles and fibers during injection molding and recycling of carbon nanotube reinforced polycarbonate composites
In this study, the characteristics of airborne particles generated during injection molding and grinding processes of carbon nanotube reinforced polycarbonate composites (CNT-PC) were investigated. Particle number concentration, size distribution, and morphology of particles emitted from the processes were determined using real-time particle sizers and transmission electron microscopy. The air samples near the operator's breathing zone were collected on filters and analyzed using scanning electron microscope for particle morphology and respirable fiber count. Processing and grinding during...
IARC Monographs Volume 111: Some Nanomaterials and Some Fibres
This volume of the IARC Monographs contains evaluations of the carcinogenic hazard to humans of fluoro-edenite fibrous amphibole, silicon carbide fibres and whiskers, and carbon nanotubes. None of these agents had been evaluated previously by the Working Group. Source: http://monographs.iarc.fr/ENG/Monographs/vol111/index.php
Évaluation de méthodes de prélèvement et de caractérisation de nanomatériaux manufacturés dans l'air et sur des surfaces des milieux de travail
La surveillance des niveaux de contamination de l'air par des nanomatériaux manufacturés (NMM) est une démarche complexe qui présente plusieurs incertitudes et limites notamment : la présence simultanée de particules de dimensions nanométriques qui ne sont pas des NMM, l'absence d'instruments validés permettant une mesure en zone respiratoire et la multiplicité des indicateurs à apprécier. Certains organismes, dont l'Institut national de recherche et de sécurité (INRS) en France et l'Institut...
'Safe handling of nanotechnology' ten years on
In 2006, a group of scientists proposed five grand challenges to support the safe handling of nanotechnology. Ten years on, Andrew Maynard and Robert Aitken — two of the original authors — look at where we have come, and where we still need to go. Source: Maynard, A. D., & Aitken, R. J. (2016). Nature Research . http://www.nature.com/nnano/journal/v11/n12/full/nnano.2016.270.html
Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice
In spite of the great promises that the development of nanotechnologies can offer, concerns regarding potential adverse health effects of occupational exposure to nanoparticle (NP) is raised. We recently identified metal oxide NP in lung tissue sections of welders, located inside macrophages infiltrated in fibrous regions. This suggests a role of these NP in the lung alterations observed in welders. We therefore designed a study aimed to investigate the pulmonary effects, in mice, of repeated exposure to NP administered at occupationally relevant doses. We therefore chose four metal oxide NPs representative...
First order risk assessment for nanoparticle inhalation exposure during injection molding of polypropylene composites and production of tungsten-carbide-cobalt fine powder based upon pulmonary inflammation and surface area dose
Inhalation exposure to low toxicity and biodurable particles has shown to induce polymorphonuclear neutrophilia (PMN) in the lungs, which is a strong indicator for lung inflammation. Recently, Schmid and Stoeger (2016) reviewed mice and rat intratracheal instillation studies and assessed the relation between particles dry powder BET surface area dose and PMN influx for granular biodurable particles (GBPs) and transition metal oxides. In this study, we measured workers alveolar lung deposited surface area (LDSA) concentrations (μm2 cm− 3) during injection molding of polypropylene (PP) car...
Refinement of the Nanoparticle Emission Assessment Technique into the Nanomaterial Exposure Assessment Technique (NEAT 2.0)
Engineered nanomaterial emission and exposure characterization studies have been completed at more than 60 different facilities by the National Institute for Occupational Safety and Health (NIOSH). These experiences have provided NIOSH the opportunity to refine an earlier published technique, the Nanoparticle Emission Assessment Technique (NEAT 1.0), into a more comprehensive technique for assessing worker and workplace exposures to engineered nanomaterials. This change is reflected in the new name Nanomaterial Exposure Assessment Technique (NEAT 2.0) which distinguishes it from NEAT 1.0. NEAT...
Taking stock of the occupational safety and health challenges of nanotechnology: 2000–2015
Engineered nanomaterials significantly entered commerce at the beginning of the 21st century. Concerns about serious potential health effects of nanomaterials were widespread. Now, approximately 15 years later, it is worthwhile to take stock of research and efforts to protect nanomaterial workers from potential risks of adverse health effects. This article provides and examines timelines for major functional areas (toxicology, metrology, exposure assessment, engineering controls and personal protective equipment, risk assessment, risk management, medical surveillance, and epidemiology) to identify...
Occupational dermal exposure to nanoparticles and nano-enabled products
Part 2, exploration of exposure processes and methods of assessment In the first of a series of two papers (Larese Filon et al., 2016), we focused our attention on identifying conditions or situations, i.e. a combination of nanoparticle physico-chemical properties, skin barrier integrity, and occupations with high prevalence of skin disease, which deserve further investigation. This second paper focuses on the broad question of dermal exposure assessment to nanoparticles and attempts to give an overview of the mechanisms of occupational dermal exposure to nanoparticles and nano-enabled products...
Occupational dermal exposure to nanoparticles and nano-enabled products
Part I - Factors affecting skin absorption The paper reviews and critically assesses the evidence on the relevance of various skin uptake pathways for engineered nanoparticles, nano-objects, their agglomerates and aggregates (NOAA). It focuses especially in occupational settings, in the context of nanotoxicology, risk assessment, occupational medicine, medical/epidemiological surveillance efforts, and the development of relevant exposure assessment strategies. Skin uptake of nanoparticles is presented in the context of local and systemic health effects, especially contact dermatitis, skin barrier...
Control banding tools for occupational exposure assessment of nanomaterials
Ready for use in a regulatory context? The development, production and application of engineered nanomaterials are becoming more and more widespread. Because researchers, developers and industrial workers are the first in line to be exposed to potentially hazardous nanomaterials, appropriate occupational exposure assessment is a key area of concern. Therefore, a number of Control Banding (CB)-based tools have been developed in order to assess and manage the potential risks associated with occupational exposure to nanomaterials.In this paper we provide a comparative analysis of different nanomaterial...
Dioxyde de titane nanométrique
De la nécessité d'une valeur limite d'exposition professionnelle Dès 2005, l'INRS a souligné la nécessité d'engager une réflexion relative aux valeurs limites d'exposition professionnelle en lien avec les nanomatériaux en raison de leurs propriétés toxicologiques particulières. Cet article propose, à partir de l'analyse de travaux initiés depuis en Europe, au Japon et aux États-Unis, une valeur limite d'exposition professionnelle pour le dioxyde de titane nanométrique...
Building a Safety Program to Protect the Nanotechnology Workforce
A Guide for Small to Medium-Sized Enterprises The National Institute for Occupational Safety and Health (NIOSH) is pleased to present Building a Safety Program to Protect the Nanotechnology Workforce: A Guide for Small to Medium-Sized Enterprises . Responsible development of nanotechnologies includes considering and managing the potential, unintended consequences to human health and the environment that might accompany development and use of the technology. This guide will demonstrate that the key to ensuring the safety of your business, particularly when resources are limited, is to prevent occupational...
Demonstration of a Modelling-based Multi-criteria Decision Analysis Procedure for Prioritization of Occupational Risks from Manufactured Nanomaterials
Several tools to facilitate the Risk Assessment and Management of manufactured nanomaterials (MN) have been developed. Most of them require input data on physicochemical properties, toxicity and scenario-specific exposure information. However, such data are yet not readily available, and tools that can handle data gaps in a structured way to ensure transparent risk analysis for industrial and regulatory decision making are needed. This paper proposes such a quantitative risk prioritisation tool, based on a Multi-criteria Decision Analysis algorithm, which combines advanced exposure and dose-response...
Nanomatériaux dans le secteur des soins de santé
Les risques professionnels et leur prévention Le domaine de la nanotechnologie connaît une évolution rapide et l'utilisation de nanomatériaux est de plus en plus fréquente. Comme dans un grand nombre de secteurs, la nanotechnologie exerce une influence croissante sur le secteur des soins de santé, ce qui accentue le risque d'exposition des travailleurs aux nanomatériaux dans leur milieu professionnel. La nanotechnologie et les nanomatériaux dans les applications médicales peuvent offrir quantité d'avantages. Par exemple...
Ecotoxicologie des nanomatériaux
Nouvelles approches analytiques Quatre ans après la publication de la note ayant pour titre « Écotoxicologie des nanoparticules : avancées méthodologiques dans l'évaluation des risques» (1), cette note a pour objectif de refaire le bilan sur les progrès réalisés dans le domaine. En effet, la période de veille écoulée a été marquée par la publication de nombreuses revues de la littérature contenant notamment le mot-clef « analytical » : concept analytique, approche...
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